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Understanding meningococcal carriage and disease in healthy teenagers

A multicentre cross-sectional study of meningococcal oropharyngeal carriage in healthy teenagers in the UK

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN72009783
Enrollment
18000
Registered
2014-12-10
Start date
2014-09-01
Completion date
Unknown
Last updated
2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Children, Primary Care

Interventions

Estimating the rate of oropharyngeal carriage of Neisseria meningitidis and the risk factors for carriage in sixth form students at a single visit with no follow up.

Sponsors

University of Oxford (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female 3. In school years 12 or 13 (S5 and S6 in Scotland) and aged 15-19 years in full time or part time education, or aged 16-19 years in the general community Target Gender: Male & Female; Upper Age Limit 19 no age limit or unit specified; Lower Age Limit 15 no age limit or unit specified

Exclusion criteria

Exclusion criteria: 1. Not willing or able to give informed consent 2. Outside the specified age range

Design outcomes

Primary

MeasureTime frame
Rates of oropharyngeal carriage of Neisseria meningitidis measured at baseline as determined by culture of Neisseria meningitidis from a throat swab

Secondary

MeasureTime frame
1. To determine rates of meningococcal carriage according to the serogroup and genogroup of cultured organisms from the throat swab 2. To identify risk factors associated with meningococcal carriage as determined by answers to a one-page questionnaire 3. To evaluate the relationship between salivary antibodies, smoking and meningococcal carriage as determined by measurements from saliva samples from Glasgow students

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026