Complex regional pain syndrome type 1 (CRPS I) (Causalgia) Nervous System Diseases Causalgia
Conditions
Interventions
Upper extremity CRPS-1: percutaneous blockade of stellate ganglion at C7 with one single injection of bupivacaine 0.25%.
Lower extremity CRPS-1: percutaneous blockade of lumbar sympat
Sponsors
Academic Hospital Maastricht (AZM) and Dutch Consortium for Research on Trauma Related Neuronal Dysfunction (TREND)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult (18 years or more) male or female patients with CRPS1 as diagnosed by International Association for the Study of Pain (IASP) criteria, with a duration of 12 months or less with moderate to severe pain (mean numerical rating scale [NRS] of more than 4 in the previous week as measured three times daily in a pain diary where, 0 = no pain and 10 = worst imaginable pain) and one extremity involved.
Exclusion criteria
Exclusion criteria: 1. Patients of less than 18 years of age 2. The existence of significant impairment of blood coagulation or the use of oral anticoagulant medication 3. Patients suffering from diabetic polyneuropathia 4. Patients who are unlikely to comply with study requirements 5. Pregnant women 6. CRPS1 with a duration of more than 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief in the first week after blockade as measured three times daily in a pain diary where, 0 = no pain and 10 = worst imaginable pain | — |
Secondary
| Measure | Time frame |
|---|---|
| The following predictors of pain relief after sympathetic blockade will be measured: 1. Pain intensity on an NRS scale of 0 to 10 2. Subjective and objective skin temperature 3. Hyper- and hypo-esthesia 4. Allodynia 5. Hyper- and hypo-algesia 6. The presence of dystonia 7. Tremor and myoclonus | — |
Countries
Netherlands
Outcome results
None listed