Two vs. one high-frequency rTMS session per day for treatment-resistant depression

Two vs. one high-frequency rTMS session per day for treatment-resistant depression: a randomized sham-controlled trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN71929667

Enrollment

Registered

2014-08-18

Start date

2006-07-01

Completion date

Unknown

Last updated

2017-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression Mental and Behavioural Disorders

Interventions

We conducted a 3-week, sham- controlled trial to assess the antidepressant efficacy of one session/day compared to two active rTMS sessions/ day (A2 group) and equivalent sham sessions once/day and tw

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Meet DSM-IV-TR criteria for current non-psychotic major depressive disorder 2. Have treatment resistant depression (with failure of at least two trials of two different antidepressants) 3. 18-59 years of age 4. Right handed 5. Be naïve to TMS

Exclusion criteria

Exclusion criteria: 1. History of seizures 2. History of head injury with loss of consciousness 3. History of brain surgery 4. History of presence of metallic implants 5. History of dementia or other Axis I diagnosis 6. History of substance dependence or abuse within the previous 6 months 7. Pregnancy

Design outcomes

Primary

Measure	Time frame
Difference from baseline in Hamilton Depression Rating Scale (HDRS) score and Clinician Global Impressions-Severity of Illness (CGI-S) score at the end of treatment and follow-up.	—

Countries

Greece

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026