Method for prevention of oxytocin-induced hypotension in caesarean delivery by mixing of phenylephrine with oxytocin

Prevention of oxytocin-induced hypotension in caesarean delivery by co-administration of phenylephrine with oxytocin: a prospective randomised double-blind controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN71886984

Enrollment

200

Registered

2012-04-04

Start date

2011-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective caesarean section under spinal anaesthesia Pregnancy and Childbirth Delivery by elective caesarean section

Interventions

After written informed consent of the patients, 200 ASA class I and ll women having elective caesarean section under spinal anaesthesia will be given either a dose of 10 IU Oxytocin plus placebo or 10

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) class l and ll undergoing elective caesarean section 2. Age between 18 to 35 years 3. Body mass index (BMI) less than 35 kg/m2 4. Spinal anaesthesia

Exclusion criteria

Exclusion criteria: 1. Placenta previa 2. Thrombocytopenia 3. Coagulopathies 4. Previous major obstetrics haemorrhage (more than 1000 ml) 5. Known fibroid 6. Receiving anticoagulant therapy 7. Anemia (hemoglobin less than 9 g/dl) 8. Body mass index greater than 35 kg/m2 9. Preeclampsia 10. Cardiac, respiratory and renal disease 11. Known allergy to any protocol medicine

Design outcomes

Primary

Measure	Time frame
Percentage drops in blood pressure (BP) below 20% of baseline after intravenous injection of oxytocin in each arm of study	—

Secondary

Measure	Time frame
Percentage of patient having nausea and vomiting after oxytocin in each arm of study	—

Countries

Brunei

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026