Cystic Fibrosis Related Diabetes mellitus (CFRD) Nutritional, Metabolic, Endocrine Diabetes mellitus
Conditions
Interventions
Children will be randomised to receive Insulin detemir 0.2 units per kg body weight by once daily subcutanous injection daily for one year. The control group will receive no intervention. There is no
Sponsors
Sheffield Children's NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Any child over ten years of age with either fasting plasma glucose more than 6.1 mmol/l but less than 7.0 mmol/l and/or a two hour glucose of more than 7.8 mmol/l but less than 11.1 mmol/l.
Exclusion criteria
Exclusion criteria: 1. Failure to provide informed consent 2. Pre-existing insulin or oral hypoglycaemic agent treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurements of beta-cell function | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Height, weight, Body Mass Index (BMI), triceps and biceps skin fold thickness 2. Respiratory function testing 3. Three monthly glycosylated haemoglobin 4. Adverse event monitoring | — |
Countries
United Kingdom
Outcome results
None listed