Planned early delivery for pregnant women with late preterm pre-eclampsia using placental growth factor testing, compared with usual care, in low- and middle-income countries

Placental growth factor testing and planned early delivery for late preterm pre-eclampsia, compared to usual care in low- and middle-income countries (PAPAGAIO-Delivery): an individualised randomised controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN71694447

Enrollment

1254

Registered

2026-02-18

Start date

2026-02-23

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy complicated by late preterm pre-eclampsia Pregnancy and Childbirth

Interventions

This is an international, multi-centre, parallel-group, individually randomised controlled trial conducted in hospitals in Sierra Leone, Zambia, India, and Brazil. Pregnant women presenting with hyper

caesarean section will be an option where indicated. Interventions – Control Group Participants allocated to the control group will receive usual care in accordance with local and international clini

Eligibility

Sex/Gender

Female

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Hypertension 2. 34+0-36+6 3. Singleton pregnancy 4. Viable fetus at the time of randomisation 5. Able to give informed consent

Exclusion criteria

Exclusion criteria: 1. In labour 2. Decision to deliver within 48 hours already made (including due to indication for immediate delivery, as defined by WHO guidelines and standard local practice)

Countries

Brazil, India, Sierra Leone, Zambia

Contacts

Public ContactAlice Hurrell

PAPAGAIO@kcl.ac.uk+44 02071883634

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026