Importance of glutamine supplementation in critical patients

Importance of glutamine supplementation in critical patients: a randomised controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN71592366

Enrollment

100

Registered

2013-10-08

Start date

2010-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parenteral glutamine dipeptides supplementation, hyperglycemic episodes, multiple trauma Nutritional, Metabolic, Endocrine

Interventions

82 multiple trauma patients were randomised to two groups of 41, independent of sex, age (20-60 years old), injury severity score (25-50). Group 1: Patients received parenteral supplementation with g

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Young patients (over 18 years) 2. With multiple traumatic lesions 3. With an ISS over 22 4. Without significant comorbidities 5. Subjects admitted to the intensive care unit (ICU) for one year

Exclusion criteria

Exclusion criteria: 1. BMI >30 kg/m^2 2. Renal or hepatic dysfunction 3. Diabetes mellitus 4. Reduced prior nutritional intake 5. Oral intake in the first 7 days

Design outcomes

Primary

Measure	Time frame
1. Plasmatic glycemia every 4-6 hours for a 6-day period using descriptive statistics 2. Daily insulin requirements using the same method above	—

Secondary

Measure	Time frame
Amount of exogenous insulin administered in this 6-day period by ANOVA analysis	—

Countries

Romania

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 20, 2026