Myocardial involvement in patients with psoriasis. Skin and Connective Tissue Diseases
Conditions
Interventions
All patients undergo cardiovascular magnetic resonance (CMR) at a 1.5 Tesla scanner with application of contrast agent to evaluate potential cardiac involvement. The images are evaluated qualitatively
Sponsors
Charité - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Signed consent 2. Age =18 years (no upper limit) 3. Verified psoriasis without any of the pre-existing conditions listed under exclusion criteria
Exclusion criteria
Exclusion criteria: 1. Absolute contraindication for MRI examination 2. Severe previous cardiac disease in particular: Condition after myocardial infarction, Condition after CABG (aorto-coronary vein bypass), Coronary artery disease with or without condition after intervention (stenting) 3. Known allergy to MRI contrast agents 4. Chronic kidney disease with GFR <30ml/min (after CKD-EPI) 5. Pregnancy, lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial T1 and T2 times determined by mapping techniques and detection and size of myocardial focal fibrosis by late gadolinium enhancement techniques and extracellular volume (ECV) by applying CMR once (single timepoint). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quantitative cardiac parameters regarding function, dimension and mass of the ventricles and atria using cine-imaging techniques by applying CMR once (single timepoint). 2. Analysis of function by measuring cardiac deformation (strain) to determine longitudinal, circumferential and radial strain by applying CMR once (single timepoint). | — |
Countries
Germany
Outcome results
None listed