Cervical cancer Cancer Malignant neoplasm of cervix uteri
Conditions
Interventions
Overall, two large groups for comparison are provided by the cross-sectional study: HPV carriers vs. not HPV-infected subjects with consequent analysis of all aspects: data on risk factors obtained by
cytological data compared in groups HPV carriers vs. not HPV-infected subjects with adequate analysis of HPV findings amongst normal cytology and further towards CIN-III. Data on different methods (LB
Sponsors
Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Inclusion criteria for the cross-sectional study: 1. Age 18-60 years 2. Presence of pathology of the cervix of any degree of severity, including minimal, suitable for colposcopy 3. Resident of Western Kazakhstan of any ethnicity 4. Absence of vaccination in the anamnesis Inclusion criteria for the case-control study: 1. All consonants to participate in the study were selected amongst women with a newly diagnosed cervical cancer 2. Any age 3. Any stage of the process 4. Histological verification of the diagnosis
Exclusion criteria
Exclusion criteria: Exclusion criteria for the cross-sectional study: 1. Non-residents 2. Vaccinated Note: HIV, 1 trimester pregnancy till 10-11 weeks are not exclusion criteria Exclusion criteria for the case-control study: 1. Non-residents of Western Kazakhstan 2. Previous medical intervention - radiotherapy, chemotherapy, surgical treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All outcomes measured at the single study visit: 1. Total HPV prevalence and in the each province of the region 2. Average viral load in HPV carriers, both in general population and in CC diseased 3. HPV leading types in general population and in CC diseased 4. % of women-carriers of HR-HPV genotypes in each age category 5. % and distribution of HPV different types in normal cytology 6. The most significant risk factors for the CC implementation 7. Probability of cervical cancer decrease (odds ratio) | — |
Secondary
| Measure | Time frame |
|---|---|
| All outcomes measured at the single study visit: 1. Results of comparison of two cytological methods operating in the region (amount of non-informative material by each method; degree of concordance with histological conclusions in each method; results of ROC analysis; Kappa statistics) 2. Colposcopic data – correlation between HPV viral load and points of the RCI (Reid colposcopic index) 3. Overall trend of CC morbidity in the region and in each age category 4. CC prognostic incidence for the nearest period 5. Detection of various HPV gene L1 isolates circulating in the region | — |
Countries
Kazakhstan
Outcome results
None listed