Facial skin microbiome Skin and Connective Tissue Diseases
Conditions
Interventions
Participants were divided into two groups, high hydration group (HHG
n = 16, = 50 A.U., arbitrary units) and low hydration group (LHG
n = 14, < 50 A.U.), according to the hydration levels in their facial cheek skin. Bacterial communities of facial skin were compared between the two groups, together with measurements of skin biophysi
Sponsors
Coway
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Healthy Korean female volunteers (age from 26–53 years)
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating 2. Performed a similar study within three months 3. Sensitive and hypersensitive skin 4. Moles, acne, telangiectasia, etc at the skin under study 5. Used similar cosmetics or took antibiotics within three months 6. Chronic diseases (asthma, diabetes mellitus, hypertension, etc) 7. Atopic dermatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurements of skin biophysical parameters and swab sampling of facial cheek skin performed just before the use of the cosmetics and at two and four weeks after use of the cosmetics: 1. Skin hydration values measured using a Corneometer CM825 instrument (Courage + Khazaka Electronic Gmbh, Germany) 2. Skin transepidermal water loss (TEWL) measured with open-chamber Tewameter TM300 (Courage + Khazaka Electronic Gmbh, Germany), according to the manufacturer’s instructions 3. Facial skin roughness analyzed using the three-dimensional (3D) skin imaging system PRIMOS® premium (GFMesstechnik GmbH, Germany) 4. Bacterial communities analyzed using pyrosequencing using a 454 GS FLX Titanium Sequencing System (Roche, Germany) at Chunlab (Korea) | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Korea, South
Outcome results
None listed