Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: a double-blinded, randomised clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN71482124

Enrollment

122

Registered

2005-10-21

Start date

2005-09-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal ulcers Eye Diseases Corneal ulcer

Interventions

Antibiotic-only or Antibiotic-steroid combination treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Bacterial corneal ulcer, defined as corneal epithelial defect and stromal inflammation of presumed bacterial origin,that is culture confirmed or gram stain positive 2. Involvement of only one eye 3. Over the age of 12 years

Exclusion criteria

Exclusion criteria: 1. Fungal, viral or amoebic keratitis 2. Known sensitivity or allergy to trial drugs 3. Perforated ulcer 4. Involvement of only functional eye, best corrected visual acuity worse than 20/200 in the uninfected eye 5. Use of topical or systemic steroids concurrently or within the past 2 months

Design outcomes

Primary

Measure	Time frame
Residual ulcer size compared to baseline	—

Secondary

Measure	Time frame
1. Time to healing (days) 2. Rate of cure or treatment failure 3. Visual acuity 4. Quality of life 5. Physician Scoring of Ocular symptoms and signs	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026