Traumatic pneumocephalus (entrance of air into the cranium after head trauma) Injury, Occupational Diseases, Poisoning Traumatic pneumocephalus
Conditions
Interventions
The patients are divided into three groups:
1. Intravenous antibiotics (IV)
2. Oral antibiotics (O)
3. Placebo (P)
In the IV group, ceftriaxone 2 g twice daily (BID) plus oral placebo will be given
Sponsors
Tehran University of Medical Sciences (TUMS) (Iran)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Traumatic pneumocephalus verified by brain computed tomography (CT) scan 2. The patients should be hospitalised less than 24 hours after trauma
Exclusion criteria
Exclusion criteria: 1. Patients who have received antibiotic therapy for other reasons 2. Individuals with penetrating traumatic brain injury, open skull fractures or operated for any causes 3. Those who are discharged from hospital with personal consent 4. All cases with life threatening lesions including severe brain, abdominal or vascular injuries and death due to other causes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of bacterial meningitis in IV, O and P groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The frequency of rhinorrhoea, intracranial haemorrhage and skull base fracture, volume and location of intracranial air in the population study and each of the IV, O and P groups. 2. The mortality rate in study population and each of the IV, O and P groups | — |
Countries
Iran
Outcome results
None listed