Time of day and influenza vaccination study

Time of vaccination and other factors, and response to the annual influenza vaccine in older adults: a cluster-randomised trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN70898162

Enrollment

400

Registered

2012-11-12

Start date

2011-10-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This study involves aspects of ageing related to the immune response following vaccination Not Applicable

Interventions

The 2 groups (morning vs afternoon vaccination) will be compared. Antibody titres, cytokine levels, sex steroids (cortisol, DHEA, testosterone etc) will be measured at baseline to determine what fact

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Available to attend surgery for morning (9-11am) or afternoon (3-5pm) vaccination and blood samples, and a fasted morning blood sample one month later.

Exclusion criteria

Exclusion criteria: No current condition such as cancer, diabetes, chronic fatigue which can affect response to vaccination. No acute infection e.g. a cold. No adverse reactions to blood sampling e.g. fainting.

Design outcomes

Primary

Measure	Time frame
Antibody response	—

Secondary

Measure	Time frame
1. Cytokine levels 2. Sex steroids 3. Psychosocial factors	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 13, 2026