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Safety and efficacy of landiolol in controlling heart rate of supraventricular tachyarrhythmias in patients with severe sepsis

Safety and efficacy of landiolol in controlling heart rate of supraventricular tachyarrhythmias in patients with severe sepsis: a randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN70831305
Enrollment
61
Registered
2013-12-10
Start date
2009-09-11
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Supraventricular tachyarrhythmias with sepsis Circulatory System Supraventricular tachycardia

Interventions

Patients were divided into two groups: those treated with landiolol (landiolol group) and those not treated with landiolol (control group) to control HR of supraventricular tachyarrhythmias. Patient

Sponsors

Kanazawa University Hospital (Japan)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. All patients who admitted to intensive care unit of the Kanazawa University Hospital from January 2006 to December 2011 2. Systemic inflammatory response syndrome score = 2 with infection 3. Supraventricular tachyarrhythmias with HR = 120 bpm for >1 h

Exclusion criteria

Exclusion criteria: 1. Less than 18 years old 2. History of chronic supraventricular tachyarrhythmias 3. Supraventricular tachyarrhythmias at the time of ICU admission

Design outcomes

Primary

MeasureTime frame
HR reduction of the supraventricular tachyarrhythmias without a decrease in arterial pressure. Arterial pressure and HR were compared between the two groups at 1, 8, and 24 h after the initiation of tachyarrhythmia.

Secondary

MeasureTime frame
The frequency of conversion to sinus rhythm. Differences of conversion rates were analyzed with Fisher?s exact test or the chi-square test as appropriate.

Countries

Japan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026