Postpartum hemorrhage (PPH) Pregnancy and Childbirth Postpartum haemorrhage
Conditions
Interventions
Once the pregnant women are seen in antenatal clinic and give informed consent to participate in the trial, they will be given either trial pack of misoprostol (600mcg) or identical placebo to be self
Sponsors
University of Liverpool (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnant women living in the recruitment villages of Mbale district at more than 34 weeks gestation 2. High risk women will not be excluded from the pilot study, even if they state their intention to deliver in a health facility
Exclusion criteria
Exclusion criteria: 1. Any pregnant woman with a known allergy to misoprostol or other prostaglandins 2. Any woman under 18 years old (unless she is an emancipated minor)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peri-partum fall in hemoglobin value of over 20% (the outcome of a fall of 2g/dl will also be tested in the pilot) following use of self-administered misoprostol after home birth | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The rate of poor maternal and fetal health at 3-5 days after delivery 2. Side effects, and safety (to include transfer to hospital, surgical intervention, blood transfusion and maternal death) The exact outcomes as well as the power calculations will only be finalized once the pilot study is completed. | — |
Countries
Uganda
Outcome results
None listed