Assessment of changes in ventilation following induced bronchoconstriction with inhaled histamine in normal subjects using Krypton-81m ventilation scintigraphy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN70267623

Enrollment

Registered

2004-09-30

Start date

2002-07-03

Completion date

Unknown

Last updated

2017-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Respiratory

Interventions

Single blind randomised controlled trial. The protocol compares histamine (to induce bronchoconstriction) with normal saline (as control) i.e. no bronchoconstriction.

Eligibility

Inclusion criteria

Inclusion criteria: Volunteers - 8, ages 18-75

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
1. To determine if ventilation scintigraphy can be used to determine and quantify regional changes in ventilation in the lung following histamine challenge in normal subjects 2. Also to determine the extent to which these correlate with changes in overall lung function	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026