Systemic inflammatory response during abdominal aortic aneurysm surgery. Circulatory System Systemic inflammatory response during abdominal aortic aneurysm surgery.
Conditions
Interventions
Blood volume expansion with either HES130/0.4, HES200/0.62 or gelatine.
This trial was carried out at Selly Oak Hospital, Birmingham, UK.
Sponsors
Fresenius Kabi (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients undergoing elective infra-renal abdominal aortic aneurysm repair using a transperitoneal route
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to any of the study solutions 2. Patients with a creatinine of greater than 177 mmol/L 3. Patients with significant iliac occlusive disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following were assessed pre-operatively, at aortic clamping, reperfusion and then at regular time points after reperfusion (2, 4, 8, 12, 48 , 72, 96 and 120 hours): Systemic inflammatory response: 1. Serum C-Reactive Protein (CRP) 2. White cell activation 3. Adhesion molecule expression 4. Endotoxin release 5. Splanchnic perfusion | — |
Secondary
| Measure | Time frame |
|---|---|
| The following were assessed pre-operatively, at aortic clamping, reperfusion and then at regular time points after reperfusion (2, 4, 8, 12, 48 , 72, 96 and 120 hours): 1. Renal dysfunction: 1.1. Urinary markers of renal injury 1.2. Serum urea and creatinine 2. Pulmonary dysfunction: 2.1. Lung injury score | — |
Countries
United Kingdom
Outcome results
None listed