Major depressive disorder Mental and Behavioural Disorders Depression
Conditions
Interventions
Real or sham repetitve transcranial magnetic stimulation (rTMS)
Sponsors
South London and Maudsley NHS Trust (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Over 18 years old, right-handed and have a diagnosis of major depressive disorder (DSM-IV)
Exclusion criteria
Exclusion criteria: 1. History of seizures 2. Head injury with loss of consciousness 3. Brain surgery 4. Presence of metallic implants 5. Evidence of dementia or other Axis 1 diagnosis 6. Substance misuse within the previous six months 7. Previous treatment with rTMS 8. Inability to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Rating Scale for Depression (HDRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical: 1. Beck Depression Inventory-II (BDI-II) 2. Visual Analogue Mood Scales (VAMS) 3. Brief Psychiatric Rating Scale (BPRS) Subjective side-effects: 1. Modified Columbia ECT Subjective Side Effects Schedule (CSSES) Cognition: 1. CAMCOG, digit-span test 2. Digit symbols modalities test 3. Grooved pegboard test Quality of life: SF-36 questionnaire Economic: Client Service Receipt Inventory (CSRI) | — |
Countries
United Kingdom
Outcome results
None listed