Cardiovascular disease, hypertension (elevated blood pressure) Circulatory System Hypertensive diseases
Conditions
Interventions
This is an observational study in people with elevated blood pressure (BP). The study will compare relationships between out-of-office blood pressure measurements, i.e. BP measurements made by study p
Sponsors
University College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men or women aged 35 years or older 2. Seated clinic systolic BP =130 mmHg or previously diagnosed with hypertension and currently taking prescription medication to lower BP 3. Wrist circumference 16-19 cm (i.e. suitable for HeartGuide watch BP monitor) 4. Willing and able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. People who are unable or unwilling to provide informed consent 2. Women who are pregnant 3. Participants with a wrist circumference >19 cm (unsuitable for the HeartGuide wrist monitor) 4. Participants with an upper arm circumference >42.0 cm (unreliable cuff-based BP measurement) 5. Participants unwilling or unable to undergo a cardiac MRI scan 6. Participants unwilling or unable to undertake a minimum of 3 consecutive weekdays of wrist blood pressure monitoring (using the HeartGuide watch BP monitor) 7. Participants unwilling or unable to undertake a continuous 24-hour period of ambulatory blood pressure monitoring 8. Participants with sustained atrial fibrillation or other significant arrhythmia (makes BP measurement unreliable) 9. People currently enrolled in another on-going clinical trial or study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. “Out of office” systolic BP, measured using the HeartGuide watch BP monitor at Baseline – Visit 1 2. Left ventricular mass index (LVMI) measured by cMRI at Baseline – Visit 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mean BP indices measured by the HeartGuide watch BP monitor at baseline – Visit 1 2. Mean BP indices measured by 24-hour ambulatory BP monitoring (ABPM) at baseline – Visit 2 3. Mean BP indices measured by seated clinic BP at baseline – Visit 1 4. Heart wall thickness measured as left ventricular mass index (LVMI) or unindexed left ventricular (LV) mass by cardiac MRI (cMRI) at baseline – Visit 3 5. Arterial stiffness measured using the Cardio-Ankle Vascular Index (CAVI) at baseline – Visit 1 6. ECG voltage criteria for LV mass measured at baseline – Visit 1 7. cMRI parameters including LVMI/unindexed LV mass, cardiac volumes and indices of vascular structure/function at baseline – Visit 3 | — |
Countries
England, United Kingdom
Contacts
Public ContactDonna Moskal-Fitzpatrick
Outcome results
None listed