Haemodialysis Urological and Genital Diseases
Conditions
Interventions
Patients were allocated either to regional citrate anticoagulation or standard heparin free haemodialysis and subsequently cross over to the alternate method. The same cohort underwent both treatment
Sponsors
Alexandra Health National Medical Research Centre
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hospital in-patients scheduled for at least 2 heparin-free hemodialysis sessions between August 2015-Jul 2016 at Khoo Teck Puat Hospital, Singapore 2. Haemoglobin >7.0g/dL 3. Haemodynamically stable 4. Reasonably functioning vascular access 5. Chronic haemodialysis patients and acute kidney injury patients
Exclusion criteria
Exclusion criteria: 1. Decompensated liver disease 2. Received blood products within last 24 hours/required blood products during the dialysis session 3. Haemostatic disorders or deranged clotting 4. Known allergy to citrate products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Thrombosis and circuit loss: at the end of the dialysis session, arterial and venous drip chambers and the filter were inspected by the nurse for visible signs of coagulation. A score of 1 (no clots), 2 (small clots), 3 (large clots) and 4 (complete clotting of circuit) was applied. 2. Anticoagulation achieved in citrate dialysis arm: post-filter iCa2+ (V) was tested at time 30, 60, 120 and 240 (just before ending) minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrolytes and calcium levels for citrate dialysis arm: pre-filter iCa2+ levels (A) were measured at 0, 30, 60, 120 and 240 minutes. Electrolytes were sent to the lab at time 0 and 240 minutes. | — |
Countries
Singapore
Outcome results
None listed