Understanding the effects of a TIPS procedure on heart function

Cardiac MRI evaluation on cardiac function and tissue in patients with liver cirrhosis compared to healthy volunteers and during follow-up after transjugular intrahepatic portosystemic shunt implantation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN69911855

Enrollment

Registered

2025-08-27

Start date

2018-02-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cirrhosis and portal hypertension Circulatory System

Interventions

Analysis of cardiac MRI in patients with liver cirrhosis and portal hypertension evaluated for transjugular intrahepatic portosystemic shunt (TIPS): pre-procedure assessment and short- and long-term f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with liver cirrhosis and confirmed portal hypertension with indication for TIPS procedure (refractory ascites or gastrointestinal variceal bleeding)

Exclusion criteria

Exclusion criteria: General contraindications to cardiac MRI (e.g. claustrophobic, metal implants)

Design outcomes

Primary

Measure	Time frame
Left and right ventricle dimension measured using cardiac MRI before and 48 h and 3 months after TIPS implantation	—

Secondary

Measure	Time frame
Left and right ventricle function, native T1-time, T2-time, extracellular volume (ECV) and fibrosis on late gadolinium enhancement (LGE) images measured using cardiac MRI before and 48 h and 3 months after TIPS implantation	—

Countries

Germany

Contacts

Public ContactElke Nickel-Szczech

elke.nickel-szczech@charite.de-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026