The effectiveness of reducing the incidence of preterm birth in IVF/ICSI twins using natural progesterone starting from the first trimester

Double-blind, placebo-controlled, single-center randomized trial to study the effectiveness of reducing the incidence of preterm birth in IVF/ICSI twins using natural progesterone starting from the first trimester

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN69810120

Enrollment

200

Registered

2014-01-31

Start date

2014-02-01

Completion date

Unknown

Last updated

2020-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labor and twins Pregnancy and Childbirth Preterm labor and twins

Interventions

Natural progesterone will be administered to the study group in the form of prontogest (IBSA Egypt) 400 mg daily through the rectal route (pessaries), starting after the first trimester scan around 12

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Healthy pregnant females in twins after IVF/ICSI with no previous history of preterm birth 2. Age > 18 years 3. Agree to be randomized at the time of the first trimester scan (12 weeks)

Exclusion criteria

Exclusion criteria: 1. Smokers 2. Major known fetal anomalies 3. Uterine anomalies 4. Cervical cerclage 5. Monochorionic twins

Design outcomes

Primary

Measure	Time frame
Delivery before 37 weeks gestation	—

Secondary

Measure	Time frame
Neonatal outcome, including: 1. NICU admission 2. Complications of prematurity 3. Neonatal death	—

Countries

Egypt

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026