Effectiveness of robotic-assisted walking (lokomat) on quality of life, gait, activity level, and balance in patients with multiple sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN69803702

Enrollment

200

Registered

2007-09-10

Start date

2007-04-10

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis Nervous System Diseases Demyelinating diseases

Interventions

All interventions will take place in a rehabilitation setting (three weeks). All interventions during the rehabilitation period (three weeks) are based on scientific evidence, on expert consensus and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 or older 2. Diagnosed with multiple sclerosis confirmed by a specialist in neurology by the mean of the McDonald criteria 3. EDSS score equal or higher than 3 and lower or equal than 7.0 4. Able to walk 14 metres (with or without assistive devices) 5. Willingness to comply with any programme to which randomly assigned

Exclusion criteria

Exclusion criteria: 1. Disorders preventing active rehabilitation (cardiovascular, respiratory, orthopaedic, psychiatric, or other medical conditions, including unhealed decubitus and orthostatic hypotension; pregnancy) 2. Rehabilitation period planned of less than three weeks 3. One or more exacerbations in the preceding three months 4. More than 135 kg 5. Strong asymmetry of musculoskeletal system 6. Length of femur less than 34 cm

Design outcomes

Primary

Measure	Time frame
1. Quality of life will be measured at baseline, at discharge (three weeks) and at 3 and 12 months 2. Activity level will be measured during seven days before the rehabilitation, in the middle week of the rehabilitation, and 3 and 12 months after discharge of rehabilitation 3. Gait-parameters (symmetry, gait security, gait speed, gait capacity) will be measured only during rehabilitation setting (at baseline, before and after the third, sixth and ninth gait intervention)	—

Measure

Time frame

1. Quality of life will be measured at baseline, at discharge (three weeks) and at 3 and 12 months 2. Activity level will be measured during seven days before the rehabilitation, in the middle week of the rehabilitation, and 3 and 12 months after discharge of rehabilitation 3. Gait-parameters (symmetry, gait security, gait speed, gait capacity) will be measured only during rehabilitation setting (at baseline, before and after the third, sixth and ninth gait intervention)

—

Secondary

Measure	Time frame
1. Pain will be measured at baseline, before and after gait interventions (each time), each day in the evening, at three weeks (discharge rehabilitation), 3 and 12 months post rehabilitation 2. Fatique will be measured at baseline, before and after gait interventions (each time), each day in the evening, at three weeks (discharge rehabilitation), 3 and 12 months post rehabilitation 3. Spasticity will be measured at baseline and discharge (at the end of three weeks rehabilitation)	—

Measure

Time frame

1. Pain will be measured at baseline, before and after gait interventions (each time), each day in the evening, at three weeks (discharge rehabilitation), 3 and 12 months post rehabilitation 2. Fatique will be measured at baseline, before and after gait interventions (each time), each day in the evening, at three weeks (discharge rehabilitation), 3 and 12 months post rehabilitation 3. Spasticity will be measured at baseline and discharge (at the end of three weeks rehabilitation)

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Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 23, 2026