Multiple Sclerosis Nervous System Diseases Multiple Sclerosis
Conditions
Interventions
1. Aerobic Training consists of 12 individual therapist-supervised 45-minute physical exercise sessions with an intensity of at least 60%VO2max in a period of 4 months
2. In the first 8 weeks one phys
Sponsors
VU University Medical Center (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of MS according to the criteria of McDonald 2. Able to walk with no more than one unilateral walking aid i.e. able to walk with no more than one unilateral walking aid 3. Suffering from fatigue, defined as a score higher than 35 on the subscale fatigue of the Checklist Individual Strength (CIS) 4. Age between 18-70 years
Exclusion criteria
Exclusion criteria: 1. Patients using in the last three months prior to inclusion Amantadine, Modafinil, Ritalin or Pemoline for their fatigue 2. Major depression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Fatigue: checklist individual strength (CIS) subscale fatigue 2. Participation: impact on participation and autonomy (IPA) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Medical outcome study short form 36 (SF36) 2. Rehabilitation activities profile (RAP) 3. Fatigue severity scale (FSS) 4. Checklist individual strength (CIS) subscales motivation, concentration, activity modified fatigue impact scale (MFIS) | — |
Countries
Netherlands
Outcome results
None listed