Comparing imaging scans and tumor tissue analysis for assessing treatment response in pancreatic cancer patients receiving chemotherapy before surgery

Discordance between pathological tumor regression grade and clinical response assessment methods in pancreatic ductal adenocarcinoma after neoadjuvant chemotherapy: implications for treatment decision-making

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN69515718

Enrollment

250

Registered

2025-10-09

Start date

2009-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer Cancer

Interventions

The participants were patients of pancreatic cancer who received neoadjuvant chemotherapy then surgical resection. Survival outcomes were analyzed comparing pathological tumor regression grades.

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Histologically confirmed pancreatic ductal adenocarcinoma (PDAC) 2. Completion of at least four cycles of neoadjuvant chemotherapy (NAC) 3. Surgical resection with curative intent 4. Available pathological TRG assessment 5. Complete clinical and follow-up data

Exclusion criteria

Exclusion criteria: 1. Other subtypes of pancreatic cancer 2. Palliative surgery 3. Incomplete pathological assessment

Design outcomes

Primary

Measure	Time frame
Overall survival was measured using the Kaplan-Meier method and Cox regression model at the time of death or last follow-up	—

Secondary

Measure	Time frame
1. Progression-free survival was measured using the Kaplan-Meier method and Cox regression model at the time of disease recurrence or last follow-up 2. Tumor regression grade was measured using CAP protocols at the pathological exam of the surgical specimens	—

Countries

Taiwan

Contacts

Public ContactTing-Kai Liao

n049550@mail.hosp.ncku.edu.tw+886 (0)6 235 3535

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 10, 2026