Resistant hypertension Circulatory System Resistant hypertension
Conditions
Interventions
On the first study visit, participants have blood samples taken for measurement of plasma renin and aldosterone using kits provided by Diagnostics Biochem Canada Inc, and a sample of blood to be sent
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Participants in both groups are followed up for one year in the hypertension clinic, with visits scheduled according to the usual routine in each clinic.
Sponsors
Grand Challenges Canada
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Blood pressure greater than 160 systolic or 90 diastolic 2.Currently on three medications including a diuretic 3. Attending the hypertension clinic at the study site 4. Aged 18 and over
Exclusion criteria
Exclusion criteria: 1. Renal failure 2. Congestive heart failure 3. Patients with a serious health condition that would limit life expectancy to less than one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure control, defined as a systolic pressure <140 mmHg and Diastolic Control is defined as a diastolic pressure <90, is measured using an automated blood pressure device at baseline and one year. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nucleotide polymorphisms (SNPs) found in the candidate genes are measured using sanger sequencing at baseline in the intervention group only. | — |
Countries
Kenya, Nigeria, South Africa
Outcome results
None listed