A randomized clinical trial to assess the postoperative pulmonary function and quality of life of preservation of the pulmonary ligament versus division of the pulmonary ligament for patients undergoing video-assisted thoracic surgery upper lobectomy

Preservation of the pulmonary ligament during video-assisted thoracic surgery upper lobectomy provide less pulmonary function damage and better quality of life for patients after operation than division of the pulmonary ligament

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN69425940

Enrollment

120

Registered

2017-11-15

Start date

2017-11-30

Completion date

Unknown

Last updated

2019-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary function and quality of life of non-small cell lung cancer (NSCLC) patients who undergoing video-assisted thoracic surgery (VATS) upper lobectomy will performed 3 months to 6 months after operation Cancer Non-small cell lung cancer (NSCLC)

Interventions

Participants are randomly allocated to one of two groups. In the preservation of the pulmonary ligament (PPL) group, patients are allocated to receive video-assisted thoracic surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who never have underwent thoracic surgery and chemotherapy before diagnosed with upper lobe non-small cell lung cancer (NSCLC) are deemed suitable for single intercostal video assisted thoracic surgery.

Exclusion criteria

Exclusion criteria: 1. Unresectable tumors 2. Older than 80-years-old 3. Deemed suitable for chemotherapy after surgery

Design outcomes

Primary

Measure	Time frame
1. Postoperative pulmonary function is measured using the variation of indicators in pulmonary function test between preoperation and postoperation at three to six months after the operation 2. Quality of life is measured using two standard questionnaires: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ–C30) and its lung cancer supplementary questionnaire (QLQ–LC13) at three to six months after the operation	—

Measure

Time frame

1. Postoperative pulmonary function is measured using the variation of indicators in pulmonary function test between preoperation and postoperation at three to six months after the operation 2. Quality of life is measured using two standard questionnaires: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ–C30) and its lung cancer supplementary questionnaire (QLQ–LC13) at three to six months after the operation

—

Secondary

Measure	Time frame
1. Complications after surgery is measured using patient notes after surgery and before discharge 2. Chest tube duration(whether thoracocentesis) is measured using patient notes after surgery and before discharge 3. The number of patients who are capable of a good cough is measured using patient notes on postoperative days one, two and three 4. Total hospital stay is measured using patient notes on discharge 5. Time in the ICU is measured using patient notes on discharge 6. Mortality within 30 days after surgery	—

Measure

Time frame

1. Complications after surgery is measured using patient notes after surgery and before discharge 2. Chest tube duration(whether thoracocentesis) is measured using patient notes after surgery and before discharge 3. The number of patients who are capable of a good cough is measured using patient notes on postoperative days one, two and three 4. Total hospital stay is measured using patient notes on discharge 5. Time in the ICU is measured using patient notes on discharge 6. Mortality within 30 days after surgery

—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026