Randomised trial of daily interruption of sedative infusions in adult medical-surgical intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN69413086

Enrollment

100

Registered

2007-04-23

Start date

2004-11-25

Completion date

Unknown

Last updated

2021-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation in critically ill patients Signs and Symptoms Sedation

Interventions

Daily interruption of sedative infusions. If during this process the patient needs sedation again then the sedation restarts at half the previous dose and adjusted to reach the desired level of sedati

Eligibility

Inclusion criteria

Inclusion criteria: Critically ill patients receiving sedation for 48 hours.

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Patients first-sedated in another hospital 3. Patients after CardioPulmonary Resuscitation (CPR)

Design outcomes

Primary

Measure	Time frame
1. Duration of stay in intensive care 2. Duration of mechanical ventilation 3. Length of stay in the hospital	—

Secondary

Measure	Time frame
1. Mortality in the intensive care 2. Mortality in the hospital 3. Doses of sedatives 4. Number of diagnostic tests of the brain	—

Countries

Greece

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026