Comparison of the effect on post-operative pain, patient satisfaction and the incidence of chronic pain by the use of either a transversus abdominis plane nerve block or a standard regime with morphine in patients undergoing surgery for total abdominal hysterectomy

Comparison of the effect of transversus abdominis plane block or conventional analgesia on pain scores, patient satisfaction and incidence of chronic pelvic pain after total abdominal hysterectomy: a randomised double-blind controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN69387981

Enrollment

Registered

2009-10-14

Start date

2008-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total abdominal hysterectomy Surgery Hysterectomy

Interventions

Patients will be randomised to receive either a bilateral transversus abdominus plane block (TAPB) using 1 mg/kg 0.375% levobupivacaine up to a maximum of 20 ml bilaterally in addition to a standard a

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. American Society of Anaesthesiologists (ASA) class I - III 2. Patients able to give written informed consent 3. Patients requiring total abdominal hysterectomy 4. Female patients aged 18 years and over

Exclusion criteria

Exclusion criteria: 1. Patients requiring total abdominal hysterectomy secondary to neoplasia 2. History of allergy to any of the medications used in the study 3. Pre-operative use of opiates 4. Patients unable to use patient controlled analgesia system

Design outcomes

Primary

Measure	Time frame
The reduction in visual analogue scores (VAS) in the post-operative period for patients undergoing total abdominal hysterectomy.	—

Secondary

Measure	Time frame
1. Usage of morphine sulphate in the post-operative period 2. Incidence of nausea and/or vomiting within the first 48 hours after surgery 3. Measurement of oxygen saturations without supplemental oxygen in both groups in the post-operative period 4. Incidence of complications associated with the analgesia techniques in both groups 5. Patient satisfaction with analgesia technique 6. Incidence of chronic pelvic pain at 3 months	—

Measure

Time frame

1. Usage of morphine sulphate in the post-operative period 2. Incidence of nausea and/or vomiting within the first 48 hours after surgery 3. Measurement of oxygen saturations without supplemental oxygen in both groups in the post-operative period 4. Incidence of complications associated with the analgesia techniques in both groups 5. Patient satisfaction with analgesia technique 6. Incidence of chronic pelvic pain at 3 months

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026