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Comparison of macular thickness and inflammatory cytokine levels after microincision versus small incision coaxial cataract surgery

Comparison of macular thickness and inflammatory cytokine levels after microincision versus small incision coaxial cataract surgery: a randomized, comparative clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN69290731
Enrollment
84
Registered
2014-01-03
Start date
2010-05-01
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract Eye Diseases Cataract, unspecified

Interventions

This prospective randomized study included 84 eyes which were randomly allocated to one of the following two treatments: 1. Phacoemulsification with microincision coaxial cataract surg

Sponsors

The National Research Foundation of Korea (NRF) (South Korea)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Eyes with nuclear density from Grade 3 to 4

Exclusion criteria

Exclusion criteria: 1. Corneal pathology 2. Pseudoexfoliation 3. History of ocular trauma 4. Intraoperative complications such as posterior lens capsule rupture, lens dislocation and ocular inflammation

Design outcomes

Primary

MeasureTime frame
1. Intraoperative measurements included: 1.1. Ultrasound time (UST) 1.2. Mean cumulative dissipated ultrasound energy (CDE) 1.3. Total balanced salt solution (BSS) use 2. Clinical measurements included preoperative, 1-week postoperative, 1-month postoperative and 2-month postoperative: 2.1. Best corrected visual acuity (BCVA) 2.2. Central corneal thickness (CCT) 2.3. Endothelial cell count (ECC)

Secondary

MeasureTime frame
Enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) were performed for IL-1alpha, IL-6, VEGF and PGE2 preoperatively and at 1 week postoperatively

Countries

Korea, South

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026