Ketamine plus morphine versus morphine alone for analgesic titration in the postoperative care unit

Ketamine plus morphine versus morphine alone as a postoperative analgesic titration strategy in adult population: a randomised and double-blinded clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN69274618

Enrollment

132

Registered

2011-02-07

Start date

2010-03-25

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative pain Signs and Symptoms Pain

Interventions

Interventional arm: A 10 cc syringe filled with 10 mg of morphine (1 mg/ml) and 20 mg of ketamine (2 mg/ml) and saline. The patient receives intravenously 2 cc of the solution every 5 minutes until a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients (aged greater than 17 years), either sex 2. Underwent surgery under general anaesthesia 3. State moderate or severe pain (pain intensity greater than 3/10)

Exclusion criteria

Exclusion criteria: 1. Patients older than 80 years 2. Use of any regional analgesic technique (including neuraxial approach) 3. History of opioid or benzodiazepines or ketamine abuse, misuse or addiction 4. Chronic (greater than 3 months) opioid-based analgesic treatment 5. Pregnancy 6. History of a severe psychiatric disorder 7. Morbid obesity (body mass index [BMI] greater than 40 kg/m2) 8. Sleep apnoea 9. Vía aérea difícil (difficult airway)

Design outcomes

Primary

Measure	Time frame
1. Pain intensity measured by categorical and numerical (0 = no pain - 10 = unbearable pain) scale at 0, 15, 30, 45 and 60 minutes after start the intervention 2. Cumulative morphine requirement	—

Secondary

Measure	Time frame
1. Cumulated incidence of vomiting (presence/absence) 2. Nausea (presence/absence) 3. Anti-emetic requirement, (yes/no) 4. Pruritus (presence/absence) 5. Sedation (Ramsay Score) 6. Respiratory depression (O2 Sat less than 90 or RR less than 10 or naloxone requirement) 7. Hallucinations (yes/no) 8. Blurred vision (yes/no) All variables will be measured at 15, 30, 45 and 60 minutes after the beginning of the intervention.	—

Measure

Time frame

1. Cumulated incidence of vomiting (presence/absence) 2. Nausea (presence/absence) 3. Anti-emetic requirement, (yes/no) 4. Pruritus (presence/absence) 5. Sedation (Ramsay Score) 6. Respiratory depression (O2 Sat less than 90 or RR less than 10 or naloxone requirement) 7. Hallucinations (yes/no) 8. Blurred vision (yes/no) All variables will be measured at 15, 30, 45 and 60 minutes after the beginning of the intervention.

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Countries

Colombia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026