Cerebral palsy Nervous System Diseases Cerebral Palsy
Conditions
Interventions
Current intervention as of 26/11/2021:
The EXECP exercise therapy intervention will have two to three supervised sessions per week during 12 weeks. The intervention will be tailored to address deficit
Sponsors
University of Jyväskylä
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current participant inclusion criteria as of 20/06/2019: Experimental group: 1. Spastic CP (diplegic or hemiplegic) 2. Male and Female 3. Age range of 9 to 24 years old 4. Gross Motor Function Classification System (Palisano et al. 2008) levels 1 to 3 Control group: 1. Typically developing 2. Male and Female 3. Age range of 9 to 24 years old Previous participant inclusion criteria: Experimental group: 1. Spastic CP (diplegic or hemiplegic) 2. Male and Female 3. Age range of 10 to 23 years old 4. Gross Motor Function Classification System (Palisano et al. 2008) levels 1 to 3 Control group: 1. Typically developing 2. Male and Female 3. Age range of 10 to 23 years old
Exclusion criteria
Exclusion criteria: 1. Pharmacological treatments (e.g. intrathecal baclofen, botullinum toxin) in the last 6 months 2. Surgical procedures in the last 6 months 3. Selective dorsal rhyzotomy 4. Dystonia 5. Inability to understand basic instructions 6. Current utilization of serial casting 7. Inability to stand with the sole of the foot flat on the floor 8. Participation in the past 3 months in a structured physical training program *Exclusion criteria 1 to 3 may be accepted as a case study (added 20/06/2019).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 20/06/2019: Gait performance is assessed using a six minute walking test. Gait kinetics/kinematics/mechanical efficiency is assessed using Vicon cameras, force plates and a heart rate monitor at pre-tests 1 and 2, and post-tests 1 and 2 for the CP group and pre-tests 1 and 2 for the control group. Previous primary outcome measure: Gait performance is assessed using a 6 minutes walking test at baseline (pre-test 1), 3 (pre-test 2), 6 (post-test 1) and 9 (post-test 2) months for participants with CP and at baseline and 3 months for control participants. | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 29/11/2021: 1. Physical activity levels are measured using electromyography and accelerometry during 7 days of normal daily living at all three periods (control, intervention and maintenance) 2. Muscle strength is assessed using Isokinetic dynamometry at pre-tests 1 and 2, and post-tests 1 and 2 for the CP group and pre-tests 1 and 2 for the control group 3. Body composition is assessed using Inbody at pre-tests 1 and 2, and post-test for the CP group and pre-tests 1 and 2 for the control group 4. Blood biomarkers, arterial stiffness is assessed through blood sampling and arteriography at pre-tests 1 and 2, and post-test 1 for the CP group and pre-tests 1 and 2 for the control group 5. H-reflex and, Post-activation depression is assessed through nerve stimulation and Electromyography at pre-tests 1 and 2, and post-tests 1 and 2 for the CP group and pre-tests 1 and 2 for the control group 6. Proprioceptive responses and corticomuscular coherence is assessed through Magnetoencephalography at pre-tests 1 and 2, and post-test 1 for the CP group and pre-tests 1 and 2 for the control group 7. Spasticity is assessed using the tonic stretch reflex threshold at pre-tests 1 and 2, and post-tests 1 and 2 for the CP group and pre-tests 1 and 2 for the control group 8. Joint Flexibility is assessed using an Isokinetic dynamometer coupled with a linear potentiometer at pre-tests 1 and 2, and post-tests 1 and 2 for the CP group and pre-tests 1 and 2 for the control group 9. Motor Function is assessed using the Gross Motor Function Measure (GMFM-66) at pre-test 2 and post-test 1 for the CP group 10. Motivational factors influencing physical activity in the intervention will be assessed using a questionnaire at the familiarization session 11. Motivational factors influencing physical activity participation will be assessed using a questionnaire at 6 and 9 months 12. Parents' motivational factors towards their children's physical activity part | — |
Countries
Finland
Contacts
Public ContactPedro Valadao
Outcome results
None listed