Randomised controlled trial for the treatment of hand arthrosis with prednisolone and naproxen

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68990076

Enrollment

246

Registered

2006-03-10

Start date

2005-12-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand arthrosis Musculoskeletal Diseases Hand arthrosis

Interventions

Patients are randomised to receive treatment with either prednisolone or naproxen or placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Hand arthrosis 2. Age over 18 years 3. Pain on a 100 mm Visual Analogue Scale (VAS) in the target hand more than 40 mm 4. Willingness to comply with the protocol

Exclusion criteria

Exclusion criteria: 1. Current treatment with steroids 2. Cardiac insufficiency 3. Infection 4. Uncontrolled hypertension 5. History of gastrointestinal bleeding 6. Diabetes mellitus 7. Allergy against study medication 8. Pregnancy

Design outcomes

Primary

Measure	Time frame
Pain in the target hand measured on a 100 mm VAS	—

Secondary

Measure	Time frame
1. Morning stiffness 2. VAS for disease activity 3. Tender and swollen joint counts (inflammatory and bony swelling) 4. Functioning measured with: a. Health Assessment Questionnaire (HAQ) b. Score for Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SACRAH) c. Arthritis Impact Measurement Scales 2 - Short Form (AIMS2-SF) d. Grip strength e. Moberg picking-up test	—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026