Gastro-oesophageal reflux disease Digestive System GI tract disorders
Conditions
Interventions
All patients will undergo a baseline endoscopy and follow up endoscopy with biopsies, then they all will undergo a wireless oesophageal 48 hour pH monitoring study, and finally these patients will be
Sponsors
Erasmus Medical Center (The Netherlands)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older 2. Symptoms of GERD as determined by the GERD-Health Related Quality of Life (HRQL) questionnaire (score more than or equal to 12) 3. Informed consent
Exclusion criteria
Exclusion criteria: 1. Aged under 18 years 2. Unable to fill out questionnaire 3. Previous history of upper Gastro-Intestinal (GI) tract cancer 4. Previous history of achalasia 5. Previous surgery to the oesophagus or stomach 6. Endoscopically demonstrated and histologically proven complicated reflux disease (ulcer, stricture, Barrett?s esophagus) 7. Coagulation disorder if uncorrected at the time of endoscopy 8. Use of warfarin or other anti-coagulant medication if uncorrected at the time of endoscopy 9. Liver cirrhosis 10. Pregnancy and lactation 11. Contraindications to the study medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the subgroups of patients with GERD symptoms in: 1. Duration of PPI treatment (four versus eight weeks) 2. Inflammatory reaction 3. Prevalence of H. pylori 4. Occurrence of symptoms | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of PPI treatment on: 1. Symptom relief 2. Inflammatory reaction in the oesophagus | — |
Countries
Netherlands
Outcome results
None listed