Effects of gustatory stimulants of salivary secretion on the pH and stimulation of saliva

Effects of gustatory stimulants of salivary secretion on the pH and stimulation of saliva: a two arm parallel single centre randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68970559

Enrollment

120

Registered

2008-10-09

Start date

2007-09-02

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Xerostomia Oral Health Diseases of salivary glands

Interventions

Salivary buffering capacity was assessed in all participants at baseline. The participants were randomly allocate to the control and intervention arms in equal numbers (60 in each arm): 1. Interventio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants (both males and females) aged over 18 years 2. Students of a Portuguese University through 3. Healthy Recruitment was supervised by research assistants.

Exclusion criteria

Exclusion criteria: 1. Presence of systemic pathology 2. Currently taking xerostomic medication

Design outcomes

Primary

Measure	Time frame
The following were assessed based on the salivary secretion rate and pH changes recorded at minute 0, 1, 2, 3, 5, 8, 10, 15 and 20 during the interventions (see interventions section): 1. GSSS induced salivary pH variations 2. Time of GSSS induced pH drop below 5.5 3. Absolute risk reduction (ARR) and number needed to treat (NNT), based on the pH variations (see primary outcomes 1 and 2 above) 4. GSSS stimulated salivary flow	—

Measure

Time frame

The following were assessed based on the salivary secretion rate and pH changes recorded at minute 0, 1, 2, 3, 5, 8, 10, 15 and 20 during the interventions (see interventions section): 1. GSSS induced salivary pH variations 2. Time of GSSS induced pH drop below 5.5 3. Absolute risk reduction (ARR) and number needed to treat (NNT), based on the pH variations (see primary outcomes 1 and 2 above) 4. GSSS stimulated salivary flow

—

Secondary

Measure	Time frame
Salivary secretion capacity defined as the difference between mechanically stimulated and basal salivary flow, expressed as ml/min.	—

Countries

Portugal

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026