Bispectral index guided induction of general anaesthesia in patients scheduled for major abdominal surgery: propofol versus etomidate

Bispectral index guided induction of general anaesthesia in patients scheduled for major abdominal surgery: single-centre double blinded crossover randomised controlled trial of propofol versus etomidate

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68690518

Enrollment

Registered

2011-03-01

Start date

2010-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anaesthesia in major abdominal surgery Surgery General anaesthesia

Interventions

The study will compare the haemodynamic effects of two intravenous induction agents which will be titrated to the appropriate anaesthesia depth monitored with bispectral index monitor. Two groups of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged over 40 years, either sex 2. American Society of Anasthesiologists (ASA) grade III 3. Scheduled for major abdominal surgery (large bowel resection, stomach resection, liver resection, Whipple resection) All patients will get an epidural catheter in the lower half of the thoracic spine.

Exclusion criteria

Exclusion criteria: 1. Alcohol-abuse 2. Drug abuse 3. Chronic use of benzodiazepines, opioides or other psychotrophic substances 4. Body mass index greater than 30 5. Anticipated difficult intubation (Mallampati 3 and 4) 6. Kidney disease (serum kreatinin greater than 120 mmol/l) 7. Manifest liver disease 8. Alzheimer disease 9. Epilepsy 10. Left ventricle ejection fraction less than 30% 11. Haemodynamic important heart valve disease 12. Pacemaker

Design outcomes

Primary

Measure	Time frame
Measured from the start of induction till 10 minutes after intubation: 1. Middle arterial pressure 2. Pulse 3. Cardiac output 4. Bispectral index 5. Oxygen saturation of haemoglobin	—

Secondary

Measure	Time frame
1. Dose of each induction agent 2. Time from start of anaesthesia induction to laryngoscopy and intubation 3. Dose of each needed rescue drug	—

Countries

Slovenia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026