Skip to content

Treatment of periodontitis non-surgically by topical melatonin and vitamin C

Evaluation of the effect of topically applied melatonin and vitamin C in non-surgical treatment of chronic periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN68604984
Enrollment
100
Registered
2024-10-02
Start date
2023-08-01
Completion date
Unknown
Last updated
2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Localized chronic periodontitis with pocket depth =5 mm Oral Health

Interventions

The intra-oral examination assessed gingival inflammation using the Gingival Index (GI), as well as measuring Probing Depth (PD) and Clinical Attachment Loss (CAL). The PD was measured from the pocket

Sponsors

Hawler Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Systematically healthy patients with localized chronic periodontitis 2. Aged 18-65 years 3. Pocket depths =5 mm

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating women 2. Smokers 3. Those who had used non-steroidal anti-inflammatory drugs, mouthwash or vitamin supplements within 3 months prior to the study

Design outcomes

Primary

MeasureTime frame
1. Presence or absence of gingival inflammation, evaluated using Gingival Index (GI) and Periodontal Disease Index (PDI) 2. Probing Depth (PD) (distance from the base of the pocket to the crest of the gingiva) 3. Clinical Attachment Loss (CAL) (distance from the base of the pocket to the cemento-enamel junction) Measured with William’s periodontal probe (MEDESY, Maniago, Italy) at four surfaces per one index tooth (mid-buccal/facial, mid-lingual/palatal, mesio-buccal and desto-buccal) Measured four times during the study, the first measurement was recorded at baseline before SRP was done (pre-treatment record), then the second record 1 week after the therapy, the third record 1 month after the intervention and after 3 months of the treatment the patients were recalled again to record clinical measures (GI, CAL and PD). The clinical examination was carried out by a single examiner who was the researcher. All researchers, the participants and statisticians were blind to the type of treatment.

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

Iraq

Contacts

Public ContactKani Mohamad Rauf
dr.kani.m@gmail.com+964 (0)7733559090

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026