Osteoarthritis of the knee Musculoskeletal Diseases Gonarthrosis [arthrosis of knee]
Conditions
Interventions
The operation will be performed in the standard manner. Normally, there is no chemical intervention to reduce blood loss. In our study, at the end of the operation and before closing the wound, the st
Sponsors
University Hospital of North Tees and Hartlepool (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Undergoing unilateral primary cemented total knee replacement
Exclusion criteria
Exclusion criteria: 1. Undergoing unilateral primary total knee replacement for trauma or tumour 2. Allergic to tranexamic acid 3. Bleeding tendency (e.g. Haemophilic and platelets disorders) 4. Warfarin, treatment dose of low molecular weight heparin (LMWH) or conventional heparin 5. History of deep vein thrombosis (DVT) and pulmonary embolism 6. Renal failure with creatinine > 250 micromole/l 7. Female subjects of child bearing potential must have a negative pregnancy test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood transfusion required (number of patients needed blood transfusion and number of units of blood transfused until patient is discharged) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The visible drain blood loss (First 48 hour) Total knee replacement is performed in bloodless field. The blood is exsangunated from the limb and tourniquet applied higher up to keep the limb bloodless. After suturing the skin and applying the pressure dressing, the tourniquet is released allowing the blood to flow into the limb. Any bleeding will be sucked out by the vacuum drain. Hence drain blood loss is good reflection of total blood loss after total knee replacement. 2. Blood loss in recovery room (visible drain blood loss just before patient leaves the recovery room) 3. Haemoglobin and haematocrit drops (on day 2 postoperatively) 4. General quality of life measure (EUROQOL) preoperative and at 3 months postoperative. This will be completed as per EuroQol group recommendation in their user guide version 1.0 November 2007.?20] 5. Oxford knee score preoperative and at 3 months postoperative. This will be completed as per authors? recommendation in their paper ?The use of the Oxford hip and knee scores? published in the Journal of Bone and Joint Surgery 2007 . Each of the 12 questions is scored from 4 to 0, with 4 representing the best outcome/least symptoms. The scores from each question were added so that the overall figure lies between 48 and 0, with 48 being the best possible outcome.There are several studies confirmed the validity, consistency and sensitivity of the above two outcome measures. 6. Length of stay 7. Cost effectiveness analysis 8. Cost analysis reflecting changes in resources utilisation (length of stay, blood transfusion, and complications treatment costs) 9. Complications | — |
Countries
United Kingdom
Outcome results
None listed