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Improvement and clinical benefit analysis of low-dose esketamine on postoperative pain and sleep after sinus surgery

Effects of esketamine on postoperative pain and sleep

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN68396064
Enrollment
145
Registered
2025-12-01
Start date
2021-07-22
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sinusitis and were scheduled to undergo functional endoscopic sinus surgery Ear, Nose and Throat

Interventions

All patients were required to abstain from food for at least 6 hours and liquids for 2 hours before surgery. Intravenous access was established, and electrocardiogram (ECG), heart rate (HR), pulse oxi

Sponsors

Twelfth Guangzhou City People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Those who were 18 to 70 years old 2. Those without severe cardiovascular, respiratory, hepatic, or renal diseases 3. Those with a preoperative American Society of Anesthesiologists (ASA) classification of I to III 4. Those whose operation time was between 8 am and 6 pm 5. Those without a history of peptic ulcer disease 6. Those without a history of addiction to analgesic drugs 7. Those without a history of migraine disease 8. Those who could cooperate with physical examination and pain assessment

Exclusion criteria

Exclusion criteria: 1. Had an operative time of less than 1 hour or more than 3 hours 2. Had an operative bleeding volume of more than 200 ml 3. Patients with intracranial hypertension 4. Psychiatric patients such as schizophrenia, delusional disorders, and epilepsy 5. Patients with severe liver and renal conditions 6. Did not cooperate with postoperative treatment and follow-up visits 7. Allergies to the study medications or developed severe infections after surgery

Countries

China

Contacts

Public ContactZi-ping Zhang
zhangzp202511@126.com+86 20-38981288

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026