Dextran studies during acute dengue infection

Studies to evaluate the functional characteristics of the microvasculature during dengue infection using dextran clearance techniques and glycocalyx volume measurements

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68309519

Enrollment

Registered

2008-07-17

Start date

2008-08-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue fever Infections and Infestations Dengue fever [classical dengue]

Interventions

In order to investigate this we will separate healthy volunteers who consent to take part in the study into two groups, 10 assigned to each of the following protocols: 1. The volunteer will rest comfo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers: 1. 20 healthy Vietnamese persons aged 18 - 30 years, either sex 2. Informed consent Patients: 1. Vietnamese adults aged 18 - 30 years , either sex 2. Admitted to Ward D at HTD with clinical dengue and evidence of vascular leakage 3. Cardiovascularly stable, not requiring intravenous (IV) fluids 4. Informed consent

Exclusion criteria

Exclusion criteria: Healthy volunteers: 1. Febrile illness within the last 3 months Patients: 1. Medical indication for IV fluid therapy 2. Refusal to consent

Design outcomes

Primary

Measure	Time frame
Comparison of dextran clearances during acute dengue infection with convalescent patterns and results from healthy controls	—

Secondary

Measure	Time frame
Comparison of glycocalyx volume measurements during acute dengue infection with convalescent values and results from healthy controls	—

Countries

Viet Nam

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026