Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock

Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock: a prospective, observational cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN68283215

Enrollment

Registered

2010-07-07

Start date

1997-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meningococcal sepsis Infections and Infestations Meningococcal infection

Interventions

Observational cohort study. Blood samples to be taken on admission, and at 24 and 48 hours thereafter.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study population consisted of previously healthy children admitted to the Pediatric Intensive Care Unit (PICU) of the Erasmus Medical Centre - Sophia Children?s Hospital between October 1997 and May 2004, suffering from meningococcal sepsis, i.e. sepsis with petechiae/purpura

Exclusion criteria

Exclusion criteria: 1. Pre-existing endocrine or chromosomal abnormalities 2. Radiation or chemotherapy within the previous 6 months

Design outcomes

Primary

Measure	Time frame
1. Blood glucose levels 2. Plasma levels of 2.1. insulin 2.2. C-peptide 2.3. cortisol 2.4. cytokines 2.5. C-reactive protein (CRP) 2.6. cytokines Measured on admission, and at 24 and 48 hours.	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026