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Measuring quality of life in patients with resistant bacterial infections (part of developing the tools to fight drug-resistant bacteria)

pREVention and management tools for rEducing antibiotic Resistance in high prevalence SEttings: Quality of Life study (REVERSE QoL)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN68194223
Enrollment
4500
Registered
2022-03-21
Start date
2022-05-01
Completion date
Unknown
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antimicrobial resistance and health-related quality of life Infections and Infestations

Interventions

Using a matched cohort study nested in the RCT (REVERSE - ISRCTN12956554) the researchers will compare quality of life among patients acquiring key pathogens of interest versus patients with a similar

Sponsors

University of Zurich
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adult patient (=18 years) admitted to a participating hospital on a participating ward 2. Able to speak/understand the local language or English well enough to fill out the surveys 3. Hospital-acquired infection caused by CRE/CRPA/CRAB or control from the same ward

Exclusion criteria

Exclusion criteria: 1. Unable to speak/understand one of the survey languages or English 2. Admitted to a ward or hospital not participating in REVERSE 3. Under 18 years of age 4. Admitted with infection caused by CRE/CRPA/CRAB (community-acquired infection)

Design outcomes

Primary

MeasureTime frame
Health-related quality of life measured using the EQ-5D questionnaire at 0, 1, 3, 6, and 12 months

Secondary

MeasureTime frame
1. Health-related quality of life measured using the SF-36 questionnaire at 0, 1, 3, 6, and 12 months 2. Differences in separate domains of both health-related quality of life questionnaires (EQ-5D and SF-36) at 0, 1, 3, 6, and 12 months

Countries

Greece, Italy, Romania, Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026