Effects of a continuous adductor canal block (ACB) added to local infiltration anesthesia (LIA) on pain and ambulation after total knee arthroplasty (TKA)

A randomised, double-blind, placebo-controlled trial with 69 patients on the effects of a continuous adductor canal block (ACB) added to local infiltration anesthesia (LIA) on pain and ambulation after total knee arthroplasty (TKA)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68176033

Enrollment

Registered

2016-10-27

Start date

2015-10-01

Completion date

Unknown

Last updated

2017-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain management after total knee arthroplasty Signs and Symptoms Pain management after total knee athroplasty

Interventions

All eligible patients are sent a letter with information about the study. At the preoperative assessment the patients sign the written consent if they wish to participate and at the same time demograp

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for primary unilateral cemented TKA under spinal anesthesia 2. Aged 50 – 90 years 3. With American Society of Anesthesiologists (ASA) physical status I-III

Exclusion criteria

Exclusion criteria: 1. Daily intake of opioids (20 mg/day of oral morphine equivalent for > 12 weeks) 2. Inability to cooperate 3. Peripheral neuropathy 4. Allergy to any of the study medications 5. Renal insufficiency (creatinine levels > 100 µmol/L and > 110 µmol/L for women and men respectively)

Design outcomes

Primary

Measure	Time frame
Peak pain levels in the operated knee during morning physiotherapy session are measured using a Numeric Rating Scale (NRS) on postoperative day 1 and postoperative day 2.	—

Secondary

Measure	Time frame
1. Pain at rest was assessed using a numerical rating scale (NRS) before the morning physiotherapy session on postoperative day 1 and 2 2. Total pain medication used by the patient from the time of admission until 48 hours after the surgery is registered and calculated into oral morphine equivalent by reviewing the patients’ medical files from the medication database “Therapy” used by Akureyri Hospital to register patient’s medications 48 hours after admission 3. Total use of antiemetics (metoclopramide, ondansetron, haloperidol and dexamethasone) is gathered by reviewing the patient’s medical files from the medication database from the drug database “Therapy” used by Akureyri Hospital to register patient’s medications 48 hours after admission 4. Mobility is assessed using the Timed Up and Go (TUG) test on the morning of postoperative day 2 5. Actual length of hospital stay is recorded by reviewing patient’s medical files right after discharge 6. Time from the end of surgery until additional pain medication is given is gathered from the medication database “Therapy” used by Akureyri Hospital to register patient’s medications at the time of discharge 7. Time taken for patient to meet ready for discharge criteria following knee replacement surgery (able to walk with crutches, use only oral analgesia, bend the operated knee =70°, climb stairs and had no acute medical problems present) is measured by reviewing medical records at the time of discharge 8. Quadriceps muscle strength is assessed by the ability of the patient to hold the affected limb up with the knee extended against resistance of the examiner (using manual muscle testing (MMT) with 0= no contraction, 1= flicker of contraction, 2= active movement with gravity eliminated, 3= active movement against gravity but not resistance, 4= active movement against gravity and some resistance and 5= normal strength) in the morning of postoperative day 1 and 2 9. Nausea is assessed on a 5-point scale (0= no nausea, 1= mi	—

Measure

Time frame

1. Pain at rest was assessed using a numerical rating scale (NRS) before the morning physiotherapy session on postoperative day 1 and 2 2. Total pain medication used by the patient from the time of admission until 48 hours after the surgery is registered and calculated into oral morphine equivalent by reviewing the patients’ medical files from the medication database “Therapy” used by Akureyri Hospital to register patient’s medications 48 hours after admission 3. Total use of antiemetics (metoclopramide, ondansetron, haloperidol and dexamethasone) is gathered by reviewing the patient’s medical files from the medication database from the drug database “Therapy” used by Akureyri Hospital to register patient’s medications 48 hours after admission 4. Mobility is assessed using the Timed Up and Go (TUG) test on the morning of postoperative day 2 5. Actual length of hospital stay is recorded by reviewing patient’s medical files right after discharge 6. Time from the end of surgery until additional pain medication is given is gathered from the medication database “Therapy” used by Akureyri Hospital to register patient’s medications at the time of discharge 7. Time taken for patient to meet ready for discharge criteria following knee replacement surgery (able to walk with crutches, use only oral analgesia, bend the operated knee =70°, climb stairs and had no acute medical problems present) is measured by reviewing medical records at the time of discharge 8. Quadriceps muscle strength is assessed by the ability of the patient to hold the affected limb up with the knee extended against resistance of the examiner (using manual muscle testing (MMT) with 0= no contraction, 1= flicker of contraction, 2= active movement with gravity eliminated, 3= active movement against gravity but not resistance, 4= active movement against gravity and some resistance and 5= normal strength) in the morning of postoperative day 1 and 2 9. Nausea is assessed on a 5-point scale (0= no nausea, 1= mi

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Countries

Iceland

Contacts

Public ContactSvava Gudmundsdottir

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026