Permissive underfeeding versus target enteral feeding in adult critically ill patients

Conditions

Enteral feeding Nutritional, Metabolic, Endocrine Enteral feeding

Hasan M. Al‐Dorzi, Abdulmajeed A. Alsadhan, Ayman Almozaini, Ali Al Bshabshe, Hani Tamim et al. (9 authors)

Critical Care Research and Practice2021-05-1823 citations

10.1155/2021/5520653

Leptin, Ghrelin, and Leptin/Ghrelin Ratio in Critically Ill Patients

Yaseen M. Arabi, Dunia Jawdat, Hasan M. Al‐Dorzi, Hani Tamim, Waleed Tamimi et al. (12 authors)

Nutrients2019-12-2122 citations

10.3390/nu12010036

Permissive underfeeding, cytokine profiles and outcomes in critically ill patients.

Arabi Y, Jawdat D, Bouchama A, Tamim H, Tamimi W, Al-Balwi M, Al-Dorzi HM, Sadat M, Afesh L, Abdullah ML, Mashaqbeh W, Sakhija M, Hussein MA, ElObeid A, Al-Dawood A.

2019-01-078 citations

10.1371/journal.pone.0209669

Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients: A Descriptive Sub-study of the PermiT Randomized Controlled Trial

Yaseen M. Arabi, Mohammed Al Balwi, Ali H. Hajeer, Dunia Jawdat, Musharaf Sadat et al. (14 authors)

Scientific Reports2018-12-145 citations

10.1038/s41598-018-36007-w

Oxidative stress, caloric intake and outcomes of critically ill patients.

Arabi Y, Jawdat D, Bouchama A, Tamim H, Tamimi W, Al-Balwi M, Al-Dorzi HM, Sadat M, Afesh L, Lehe C, Almashaqbeh W, Sakhija M, Al-Dawood A.

2018-12-105 citations

10.1016/j.clnesp.2018.11.011

Caloric intake and the fat-to-carbohydrate ratio in hypercapnic acute respiratory failure: Post-hoc analysis of the PermiT trial.

Al-Dorzi HM, Aldawood AS, Tamim H, Haddad SH, Jones G, McIntyre L, Solaiman O, Sakhija M, Sadat M, Afesh L, Kumar A, Bagshaw SM, Mehta S, M Arabi Y.

2018-11-132 citations

10.1016/j.clnesp.2018.10.012

Permissive underfeeding or standard enteral feeding in critically ill adults

Kerrie Aldridge

Journal of the Intensive Care Society2015-09-18321 citations

10.1177/1751143715607732

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults.

Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, Mehta S, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L, PermiT Trial Group.

2015-05-20399 citations

10.1056/nejmoa1502826

Permissive underfeeding versus target enteral feeding in adult critically ill patients (PermiT Trial): a study protocol of a multicenter randomized controlled trial.

Arabi YM, Haddad SH, Aldawood AS, Al-Dorzi HM, Tamim HM, Sakkijha M, Jones G, McIntyre L, Mehta S, Solaiman O, Sadat M, Afesh L, Sami B.

2012-10-1218 citations

10.1186/1745-6215-13-191

Interventions

All patients admitted to ICU will be screened within first 48 hours for eligiliblity and all potential eligible candidates will be identified. Patients will be allocated to one of the two groups:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Receiving enteral feeding 2. Aged greater than or equal to 18 years, either sex 3. Expected to stay 48 hours or more in the ICU

Exclusion criteria

Exclusion criteria: 1. Terminal illness 2. Do not resuscitate (DNR) order (no code, no escalation) in the first 48 hours 3. Enteral feeding cannot be started within 48 hours of admission 4. Total parenteral nutrition (TPN) 5. Oral feeding 6. Previously enrolled in this study within the same hospital admission 7. Brain death within 48 hours of admission 8. Pregnancy 9. Post-liver transplant 10. Post cardiac arrest 11. Burn patients 12. Prisoners 13. Elderly subjects aged greater than 80 years 14. Patients on more than one ionotropic support at maximum dose

Design outcomes

Primary

Measure	Time frame
90 day-all cause mortality: death before or at day 90 of enrolment	—

Secondary

Measure	Time frame
1. ICU mortality: death in the ICU during the same ICU admission 2. Hospital mortality: death in the hospital (in ICU or on floor) during the same hospital admission 3. 180-day mortality: death before or at day 180 of enrolment 4. Daily Sequential Organ Failure Assessment (SOFA) scores recorded on days 1, 3, 7, 14, 21 and 28	—

Countries

Bahrain, Canada, Germany, Saudi Arabia, United Arab Emirates

Outcome results

None listed