A trial comparing conventional fractionation with 'CHART' in the treatment of head and neck cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN68133429

Enrollment

500

Registered

2001-02-28

Start date

1990-01-01

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cancer Head and neck

Interventions

Conventional radiotherapy arm - 2 Gy, once daily five days a week over six weeks (large volume - 44 Gy in 22 fractions followed by small volume - 16 Gy in eight fractions) CHART arm -

Eligibility

Inclusion criteria

Inclusion criteria: 1. Histologically proven squamous cell carcinoma of all grades at one of the following sites: Nasal sinuses, Nasopharynx, Oral cavity, Oropharynx, Hypopharynx, Carcinoma of the larynx 2. A radical course of external beam radiotherapy is the appropriate sole treatment

Exclusion criteria

Exclusion criteria: There should be no evidence of distant metastases beyond the regional nodes in the neck

Design outcomes

Primary

Measure	Time frame
1. Local tumour control 2. Survival 3. Morbidity	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026