Symptomatic (stroke/TIA/amaurosis fugax) carotid artery stenosis Circulatory System Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
Conditions
Interventions
1. Aspirin (75 mg orally [po] once daily [od]) and dipyridamole SR (200 mg po twice daily [bd])
2. Aspirin (75 mg po od) and clopidogrel (300 mg po loading dose following by 75 mg po od)
Patients ran
Sponsors
St George's Heathcare NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Women or men aged greater than 18 years 2. Patients with greater than or equal to 50% carotid artery stenosis 3. Symptoms of TIA or stroke within the last month 4. Baseline magnetic resonance imaging (MRI) or computed tomography (CT) imaging has been performed 5. Consented to take part in the study
Exclusion criteria
Exclusion criteria: 1. Currently taking antiplatelet/antithrombotic medication other than aspirin (although low does prophylactic subcutaneous heparin for deep vein thrombosis [DVT] prophylaxis will be allowed) 2. Patients with prosthetic heart valves who have gaseous embolic signals 3. Where clopidogrel or dipyridamole is contra-indicated 4. Carotid endarterectomy planned within the next month 5. Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of embolic signals (using international consensus criteria) detected during transcranial doppler recording from ipsilateral middle cerebral artery at 48 hours after study entry. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed