Acute Respiratory Distress Syndrome (ARDS) Respiratory Respiratory disorders
Conditions
Interventions
Baseline measurements were performed in the supine position after one hour of steady-state conventional mechanical ventilation. Then the following two periods of PP were randomised:
1. 6 hours of PP
Sponsors
Sainte Marguerite Hospital (France)
Eligibility
Inclusion criteria
Inclusion criteria: Twenty consecutive patients with ARDS were included and turned prone in the medical intensive care unit of Sainte Marguerite University Hospital in Marseille, France. Patients were prospectively included in this study after obtaining written informed consent from the next of kin. The study design was approved by the Comité Consultatif de Protection des Personnes dans la Recherche Biomédicale of Marseille. ARDS was defined in accordance with the recommendations of the American/European Consensus Conference.
Exclusion criteria
Exclusion criteria: Patients with unstable cardiovascular function, cerebral injury or unstable spinal fractures, patients subjected to major abdominal surgery and patients with a history of neuromuscular disease were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Intra-Abdominal Pressure (IAP) 2. Plasma Disappearance Rate of Indocyanine Green (PDRICG) 3. Extravascular Lung Water (EVLW) 4. Partial Pressure of Oxygen in Arterial Blood (PaO2)/Fraction of Inspired Oxygen (FiO2) ratio 5. Central Venous Pressure (CVP) 6. Mean pulmonary arterial pressure 7. Pulmonary artery occlusion pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
France
Outcome results
None listed