Cognitive function in haemodialysis patients Mental and Behavioural Disorders
Conditions
Interventions
This is a randomised study, meaning participants are assigned by chance to one of two groups for 1 year:
1. Dialysis fluid is set at 37°C (normal body temperature)
2. Dialysis fluid is set at 0.5°C be
blood results, hospital admissions, and heart-related events will be reviewed every 3 months. Safety will be monitored throughout the study.
Sponsors
University Hospitals of Derby and Burton NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. The participant is receiving maintenance in-centre haemodialysis 2. Over 18 years of age at time of consent 3. The participant is able and willing to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Participants with confirmed diagnosis of dementia 2. Participants who lack capacity to consent 3. Participants having dialysis less than three times a week 4. Pregnant participants
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Other cognitive domains: processing speed, inhibition, attention, perception and general cognition and memory measured using Digit symbol matching task, Flanker Test and Letter Number Sequence Task at baseline and 12 months 2. Clinical outcomes, namely, number and length of hospitalisation episodes and frailty score measured by the clinical frailty score at baseline and 12 months 3. Quality of life measured by the Short Form Health Survey Questionnaire (SF-36) at baseline and 12 months 4. Adverse events and serious adverse events related to intervention, cardiovascular events and cerebral ischaemic events recorded at baseline, 3, 6, 9 and 12 months | — |
Countries
England, United Kingdom
Contacts
Public ContactDerby Clinical Trials Support Unit
Outcome results
None listed