Typhoid fever Infections and Infestations Typhoid fever
Conditions
Interventions
An open randomised two-way comparison of gatifloxacin (10 mg/kg/day) versus azithromycin (20 mg/kg/day) for seven days for the treatment of symptomatic uncomplicated typhoid fever.
Sponsors
University of Oxford (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Patients will be eligible if they have suspected or culture proven enteric fever provided: 1. They give fully informed consent 2. They are not obtunded not jaundiced 3. There are no signs of gastrointestinal (GI) bleeding or any other evidence of severity (see below) 4. No history of hypersensitivity to either of the trial drugs 5. No treatment with a quinolone or 3rd generation cephalosporin or macrolide within one week of hospital admission 6. They are not pregnant
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation 2. Any signs of symptoms of severe disease 3. No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fever Clearance Time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical and Microbiological Failure. | — |
Countries
Viet Nam
Outcome results
None listed