Type 2 diabetes Nutritional, Metabolic, Endocrine Type 2 diabetes mellitus
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with a diagnosis of type 2 diabetes >6 months 2. Males and females 3. Aged 18-70 years 4. Ability to understand English (to provide informed consent)
Exclusion criteria
Exclusion criteria: 1. Use of insulin and GLP-1 analogues 2. History of gastroparesis or gastric surgery 3. Coeliac disease/wheat intolerance 4. Irritable bowel syndrome 5. HbA1c >75 mmol/mol 6. Pregnancy/breastfeeding 7. Excess alcohol intake 8. Glucose-lowering drug dosage adjustment within the previous month 9. Antibiotics in the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At each visit using blood test: 1. Incremental area under the 3 h glucose response curve (IAUC). Sample timepoints are 0, 15, 30, 45, 60, 75, 90, 120 and 180 min. | — |
Secondary
| Measure | Time frame |
|---|---|
| At each visit using blood test: 1. Incremental area under the 3 h insulin response curve (IAUC). Sample timepoints are 0, 15, 30, 45, 60, 75, 90, 120 and 180 min. 2. Peak glucose. 3. Peak insulin. 4. Time-to-peak glucose. 5. Time-to-peak insulin. 6. Matsuda Index. 7. Insulinogenic index. | — |
Countries
England, United Kingdom